A CONCISE REVIEW ON PYRAZOLINE DERIVATIVE FOR DIABETES MELLITUS

E. Ajila*, R. Aniz K. Roy, S. M. Sandhya, A. S. William Arputha Sundar, M. S. Padmaja Devi1 and Lakshmi Gopal R.

ABSTRACT

The N-phenyl Pyrazoline ring with aryl substitution at third and fifth position exhibits better biological activities. The most common procedure for the synthesis of 2-pyrazolines is the reaction of an aliphatic or aromatic hydrazine with α,β-unsaturated carbonyl compounds. 2-Pyrazolines synthesized by the cycloaddition of diazomethane with substituted chalcones. 2-Pyrazolines can also be prepared by the condensation of chalcone dibromide with hydrazine. A number of diarylidene cycloalkanones on reaction with hydrazine hydrate produce pyrazolines. Dipolar cyclo addition of nitrilimines to dimethyl fumarate, fumaro nitrile and the N-aryl maleimides yields the corresponding pyrazolines. Reaction of Et 2-(phenylazo)-3-oxobutanoates with nicotinic acid hydrazide using glacial acetic acid gives pyrazoline derivatives. Diabetes mellitus is a common and very prevalent disease affecting the citizens of both developed and developing countries. It is estimated that 25% of the world population is affected by this disease. Most patients can be classified clinically as having either Type 1 diabetes mellitus. Historically, different substituted pyrazoles were known for their hypoglycemic activity, but in a search for novel structural classes of drugs inhibiting the activity of the ATP-K + channel of the beta cell pancreatic membrane, inducing the production of insulin we turned our attention to substituted pyrazoline derivatives.

Keywords: Pyrazoline, Phenyl hydrazine, Acetophenone, Aldehyde, Diabetes mellitus.