EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

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An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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Abstract

DEVELOPMENT AND VALIDATION OF AN RP-HPLC METHOD FOR ESTIMATION OF MOXONIDINE IN BULK AND FORMULATION

Tejavath Venu*, Dr. M. Dhanalakshmi and Md. Asra Farheen

ABSTRACT

A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Moxonidine, in its pure form as well as in tablet dosage form. Chromatography was carried out on a Phenomenex Luna C18 (4.6 x 250mm, 5μm) column using a mixture of Methanol and Water (75:25% v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 223nm. The retention time of the Moxonidine was 2.7 ±0.02min. The method produce linear responses in the concentration range of 20-100ppm of Moxonidine. The method precision for the determination of assay was below 2.0% RSD. The method is useful in the quality control of bulk and pharmaceutical formulations.

Keywords: Moxonidine, RP-HPLC, validation.


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SJIF Impact Factor: 7.065

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