FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF FAMOTIDINE USING SUPERDISINTEGRANTS

V. Jhansi Priya Marabathuni*, G. Nireesha, I. Adilakshmi, J. Krishnaveni, K. Anjaneya Gupta, K. Venkata Lakshmi and Ch. M. M. Prasada Rao

ABSTRACT

The objective of the present investigation was to prepare oro dispersible tablets of Famotidine, because of their convenience in administration and suitability for patients having dysphagia. Tablets were prepared by direct compression using sodium starch glycolate and croscarmellose sodium and crospovidone as superdisintegrants. Microcrystalline cellulose pH-102 was used as diluent and mannitol, sodium saccharine to enhance the organoleptic properties of tablets. The tablets were evaluated for weight variation, hardness, friability, assay, invitro disintegration time, in-vitro dissolution study. Hardness and friability data indicated good mechanical strength of tablets. The results of in-vitro disintegration time indicated that the tablets dispersed rapidly in mouth within 60 seconds. It was concluded that superdisintegrants addition technique is a useful method for preparing oro dispersible tablets by direct compression method.

Keywords: Oro dispersible tablets, Famotidine, Superdisintegrant, Sodium starch glycolate, Croscarmellose sodium, Crospovidone.