UV SPECTROPHOTOMETRIC DETERMINATION OF CANDESARTAN CILEXETIL IN BULK DRUG

Parbati Kirtania Roy*, Nasema Begum and Mohd. Amrin Sultana

ABSTRACT

Candesartan Cilexetil (Candesartan) is a medication utilized for the treatment of Hypertension. It is in a class of medication containing angiotensin receptor blocker (ARB). The main objective of the present work is to determine a simple, precise and cost effective UV Spectrophotometric The wavelength of Candesartan Cilexetil using UV Spectrophotometric was detected at 246nm in Acetonitrile and it obeys Beer’s law in a concentration range of 4- 24μg/ml with a correlation coefficient of 0.999. This method was validated for linearity, accuracy, precision, limit of detection, limit of quantification. The %RSD was found to be <2.0% in all cases and all the validation parameters were found to be within the limits. The proposed methods were suitable for the quantitative determination of Candesartan Cilexetil in bulk drug.

Keywords: Candesartan Cilexetil, UV Spectrophotometer, Acetonitrile, Validation.