SECONDRY METABOLITS OF INULA CASPICA

B. DJ. Komilov, K. A. Eshbakova* and N. DJ. Abdullaev

ABSTRACT

The chemical constituents of the flavonoids, terpenoids, coumarins and sterols of Inula caspica (family Asteraceae) aerial parts, growing in Uzbekistan was investigated by column chromatographic methods to isolate eight known compounds. Their structures were established on the basis of physicochemical and spectral parameters (UV, IR and PMR) and were identified as chrysoeriol, luteolin, kaempferol, quercetin, luteolin-7- O-β-D-glucoside, badrakemin, gaillardin and stigmasterol-ß-D-glucopyranoside. Anticancer activity of the gaillardin and chloroform fraction has been studied. Compounds - chrysoeriol, luteolin, kaempferol, quercetin, luteolin-7- O-β-D-glucoside, badrakemin, gaillardin and stigmasterol-ß-D-glucopyranoside were isolated from Inula caspica for the first time.

Keywords: Inula caspica, Asteraceae, Uzbekistan, chrysoeriol, luteolin, kaempferol, quercetin, luteolin-7-O-?- D-glucoside, badrakemin, gaillardin, stigmasterol-ß-D-glucopyranoside, NMR-spectrum.