STEREOTACTIC BODY RADIOTHERAPY (SBRT) AND OLIGOMETASTATIC BLADDER CANCER: ABOUT A CASE AND REVIEW OF THE LITERATURE

Mane Maimouna*, Benkhaled Sofian, Van Gestel Dirk and Otte François-Xavier

ABSTRACT

Purpose: The term “oligo-metastasis” could be defined as a transition state between localized and widespread systemic cancer. In the uro-oncology field, very few cases of oligo-metastases of bladder cancer have been described, probably because of the high metastatic potential of muscle invasive bladder cancer. In fact, bladder cancer remains an important cause of morbidity and mortality, the latter being predominantly related to metastasis. Herein we report a case of an oligometastatic bladder cancer treated by SBRT and we review the literature on the treatment of this disease. Methods: We describe a case of pulmonary and lymph-node metastases of a high grade bladder cancer, which relapsed after surgical resection and chemotherapy. Results: After the patient was treated with SBRT at his 3 metastatic lesions, and dispite a transient episode of grade 2 dyspnea, he was clinically in good condition without any evidence of disease on PET-CT scan after 22 months. Conclusion: SBRT is an efficient metastasis-directed treatment, and may be an alternative to chemotherapy or surgery. However, our case highlights that SBRT although easily feasible is not without any risk and should be use with caution, especially outside recognize indications and clinical trials.

Keywords: SBRT, oligometastasis, bladder cancer.