FORMULATION AND EVALUATION OF MINOCYCLINE HYDROCHLORIDE EXTENDED RELEASE MATRIX TABLETS

Arigela Bharathi*, Vaida Aswini Priya, Nadikatla Anusha, Sali Roja, Garikipati Priyanka

ABSTRACT

The present study was aimed to formulate and evaluate minocycline hydrochloride (MIN) extended release matrix tablets, using natural polymers like Guar gum and Tara gum, individually and in combination in order to maintain MIN concentration in the blood over a period of time (24 hrs). Totally, seven formulations and in-vitro drug release studies were carried out in 0.1N HCl up to 2 hrs and in pH 7.4 buffer for remaining 22 hrs respectively. Based on the in-vitro drug release profiles, formulations F7 (combination of Guar and tara gum- 12.5%:12.5%) resulted in extended delivery of MIN (61.59%) for a period of 24 hours. Formualtion F6 containing guar gum at 37.5%w/w showed a 71.5 % release of MIN at the end of 24 hrs. Mathematical treatment of the in vitro drug release data suggests that, all the formulations fitted into first order release kinetics. Drug release from the matrix occurred by combination of two mechanisms, diffusion of drug from tablet matrix and anamolous transport, which was reflected from Higuchi's model and Korsmeyer peppas equation. Overall, combinatiomn of guar and tara gums significanlty slowed the release of MIN form tablets.

Keywords: Minocycline hydrochloride, Guar gum, Tara gum, extended release, matrix tablets.