PEROXISOME PROLIFERATOR- ACTIVATED RECEPTORS FAMILY OVERVIEW

Feryal Hashim Rada*

ABSTRACT

Nuclear receptor superfamily comprised of many receptors such as retinoic acid, thyroid hormone, steroid, and Peroxisome Proliferator- Activated Receptors (PPARs). The binding of Peroxisome Proliferator- Activated Receptor with its ligand and then with retinoid X receptor will lead to form a heterodimer complex, which has a transcription factors activity on many target PPAR responsive genes. The PPAR exist as three forms alpha (α), delta (δ) and gamma (γ) that have important roles in expression of gene that regulate many biological processes such as metabolism and deposition of lipid, metabolism of glucose, and reaction of inflammation.

Keywords: Peroxisome Proliferator- Activated Receptors (PPARs), vasoprotective, insulin sensitivity, inflammation.