CLINICAL COMPARATIVE STUDY FOR THE EFFECT OF ANTIHYPERTENSIVE DRUGS ON SERUM OXIDANT-ANTIOXIDANTS STATUS

Ruaa. K. Abbas, Prof. Dr. Raid M. H. Al-Salih* and Assist Prof. Dr. Sajid. H. Guzar

ABSTRACT

The aim of this study was to investigate the effect of antihypertensive drugs on serum oxidant-antioxidants status. Using the lipid peroxidation marker, malondialdehyde (MDA) and preventative antioxidants ceruloplasmin (Cp) and albumin (Alb), in serum of patients with hypertension. Blood samples were obtained from (160) patients treated with different antihypertensive drugs, as well as (40) healthy subjects as a control group. They divided into five groups as the following: control Group:- Included forty healthy subjects aged (40-70 years). ACEIs Group:- Included forty patients with Angiotensin-Converting Enzyme Inhibitors (ACEIs) drugs aged (40-70 years). ARBs Group:- Included forty patients with Angiotensin-II Receptor Blockers (ARBs) drugs aged (40-70 years). β.blockers Group:- Included forty patients with Beta.blockers drugs aged (40-70 years). CCBs Group:- Included forty patients with Calcium Channel Blockers (CCBs) drugs aged (40-70 years). Results: The results show non-significant differences in serum MDA between each of ACEIs and ARBs drugs groups, in comparison with control group (P≤0.05). While a significant increase in the levels of serum MDA can be observed in two patients groups with β.blockers and CCBs drugs in comparison with control group when compared with groups of ACEIs and ARBs drugs. Ceruloplasmin (CP) also shown significant increase in all patient groups in comparison with control group, as well as significant increase in the levels of serum CP can be observed in β.blockers and CCBs drugs groups in comparison with groups of ACEIs and ARBs drugs, While serum albumin (Alb) levels have non significantly (P≤0.05) differences in all patients groups.

Keywords: Hypertension, Antihypertensive drugs, Oxidant-antioxidants Status.