GLAVANOID AN EMERGING NUTRIGENOMICS TO TREAT OBESITY

J. Balasubramanian*, G. Sai Prasanna Lakshmi, K. Jothi, G. Adinarayana

ABSTRACT

Over the last two decades there has been an upsurge interest in the impact of the gastrointestinal tract on appetite regulation. Much of the focus has been on the neuronal and hormonal relationship between the gastrointestinal tract and the brain. This retrospective approach of the present work provides novel information on how treat obesity using Glavanoid as a major neutraceutical source from Glycyrrhiza glabra L. Glabridin is the major chemical constituent involved in anti obesity effect. Glabridin effectively inhibited adipogenesis in 3T3-L1 cells. Moreover, LSC showed inhibitory effect on adipogenesis in a dose-dependent manner. Genetic differences play an important role in the development of obesity, although it is clear that these are by no means the only contributing factors. Environmental and social factors are also very important. The term ‗nutrigenomics‘ is generally used to refer to the impact of genetic variation on optimal dietary requirements for an individual. Nutrigenomics which represents a new approach in nutrition research that joints the application of powerful functional genomics technologies, bioinformatics and molecular biology with more traditional methodologies may orientate the design and development of new functional foods for obesity, based on the scientific knowledge of the impact of specific nutrients on the mammalian body weight control system and their mechanisms of action.

Keywords: Glavanoid, Glabridin, Adipogenesis, Nutrigenomics.