STUDIES ON FORMULATION AND CHARACTERIZATION OF TOPICAL EMULGEL CONTAINING MICROSPONGES OF MEFENAMIC ACID

Shuhaib B.* and Dr. Suja C.

ABSTRACT

The objective of the present investigation was formulate & characterize the microsponge of mefenamic acid, these microsponges were prepared by quassi-emulsion method. Preformulation studies by FTIR, revealed no interaction between pure drug and the different polymers used. The prepared microsponges were characterized for their production yield, drug content, mean particle size & entrapment efficiency, Effect of formulation variable were also studied. The microsponge containing 0.5 gm of poly vinyl alcohol, 0.6 gm of ethyl cellulose and 5ml ethanol good were compared to the other formulation prepared. The best microsponges (M3, M6, M9) in cooperated into emulgel. The topical emulgel was evaluated for their organoleptic characters, viscosity, spreadability, drug content and drug release studies. From that MEG1 Shows better compared to other formulation. Permeation from mefenamic acid gel followed Higuchi model or matrix diffusion. In mefenamic acid microsponge emulgel drug seem to follow first order kinetics as it is evidenced by correlation coefficients (r2=0.9846 to 0.974) which is better than zero order (r2 =0.9496 o 0.9318) Higuchi’s plot was also found to be linear for all formulations with regression coefficient ranging from 0.9024 to 0.7931. Hence, to confirm the exact mechanism of drug permeation from these microsponges, the data was fitted according to the Korsmeyer-Peppas model.

Keywords: microsponge, mefenamic acid,ethyl cellulose, emulgel, release kinetics.