HEPATOPROTECTIVE ACTIVITY OF A POLYHERBAL FORMULATION-CHATHURMUKA CHOORANAM

Revathi S. and Saraswathi U.*

ABSTRACT

Aflatoxins (AFB1) are secondary metabolites of Aspergillus flavus and Aspergillus parasiticus which they contaminate the animals and humans to produce liver toxicity. The present study is to assess the effect of hydroethanolic extract of the polyherbal formulation Chathurmuka chooranam (CMC) on AFB1 induced Wistar rats. AFB1 is induced at a dosage of 250 μg/kg/i.p for 7 days and the hydroethanolic extract at a rate of 250 and 500 mg/kg/p.o for the next 7
days. The effect of hematological parameters (WBC, RBC and Hb), serum marker enzymes (AST,ALT and ALP), lipid profile (Total cholesterol, triglycerides, LDL,VLDL and HDL) and other biochemical parameters(urea, uric acid, creatinine and bilirubin) was evaluated. The results revealed there was an increment in the levels of haematological parameters, decrement in the activites of serum marker enzymes and normal level of lipid profile after treatment with the polyherbal extract to the AFB1 induced animals. In conclusion, the present study demonstrate the effect of aflatoxin induced toxicity was reversed after the treatment with polyherbal extract.

Keywords: Aflatoxin B1, CMC, Serum marker enzymes, Haematological parameters.