HYPERURICEMIA AND ALBUMINURIA IN TYPE 2 DIABETES MELLITUS PATIENTS

Amram R. Marak, *Harish Sugathan, Selvarajan Chettiar, Rakul Nambiar K. and Anjali Srikumar

ABSTRACT

Introduction: Hyperuricemia is considered to be an independent risk factor for renal dysfunction in diabetics and albuminuria can be used as a surrogate marker of early diabetic nephropathy. We studied the correlation between hyperuricemia and albuminuria in type 2 diabetes mellitus patients. Materials and Methods: In a cross-sectional study of 90 patients (45 men and 45 women) with type 2 diabetes mellitus, serum uric acid, albuminuria and urinary albumin-creatinine ratio were determined. Other parameters namely blood pressure, body mass index, serum cholesterol, serum triglycerides, glomerular filtration rate and fasting blood glucose were also assessed. Results: The mean age of the study population was 61.49 ± 11.4 years. Serum uric acid levels for normoalbuminuric, microalbuminuric, and macroalbuminuric patients were 5.01 ± 1.46, 6.8 ± 1.16 and 8.58 ± 0.42mg/dL respectively. Serum uric acid level had a significant positive correlation with urinary albumin creatinine ratio even after adjustment for age, sex, body mass index, insulin use, smoking, diabetes duration, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, serum cholesterol, triglycerides, and calculated creatinine clearance. There was also significant association between hyperuricemia and serum triglyceride, fasting blood glucose, cholesterol levels, glomerular filtration rate, serum creatinine levels, age, duration of diabetes mellitus, and body mass index. Conclusions: We demonstrated that serum uric acid levels have a significant independent positive correlation with albuminuria.

Keywords: Type 2 diabetes, hyperuricemia, diabetic nephropathy, albuminuria.