OLFACTORY ESTHESIONEUROBLASTOMA: STUDY OF 5 CASES AND REVIEW OF THE LITTERATURE

Khaoula Hafidi*, Omar Oubry, Hasnae Taghzout, Zineb Alami, Touria Bouhafa and Khalid Hassouni

ABSTRACT

Introduction: Esthesioneuroblastoma is a rare malignant tumor, which develops from olfactory neuroepithelium and is one of the rarest tumors of the nasal cavity. The aim of this study is to specify through a review of the literature, histoclinic characteris- tics, therapeutic terms and prognostic factors of this tumor. Material and methods: a retrospective study concerning five cases of olfactory neuroblastoma treated in the department of radiation therapy at the departmentof radiotherapy University hospital Center Fes Morocco. Results: The mean age of our patients was 40 years. Clinical symptomatology was dominated by nasal obstruction and epistaxis. Four patients were classified as Kadish C and one patient as Kadish D. Four patients underwent surgical treatment, 3 of them had postoperative radiotherapy. One patient was above all therapeutic resources. One patient is in complete remission with a mean follow-up of 3 years. Conclusion: olfactory esthesioneuroblastoma is a rare sinonasal malignant tumor, characterised by clinical polymorphism and local agressivity. In spite of the surgery and the radiotherapy, the forecast remains reserved in the long term.

Keywords: Olfactory neuroblastoma, Imagery, Immunohistochemestry, Surgery, Radiotherapy.