STUDY OF PROTECTIVE EFFECTS OF PISTACIALENTISCUS LEAVES AQUEOUS EXTRACT AGAINST GASTRIC ULCER AND RENAL STONE FORMATION IN RATS

Rachida Aboufatima, Jawad Laadraoui, Mehdi Ait Laaradia, Kenza Bezza, Zineb El Guebbas, Sara Oufquir, Hind Ferehan, Abderrazak EL Alami, Sokar Zahra and Abderrahman Chait*

ABSTRACT

Medicinal plants have been used by all societies since ancient times as medicines for the treatment of many diseases. In Morocco, the use of medicinal plants is an important part of the cultural diversity of population. The objective of this data is to investigate the protective effects of the aqueous extract of Pistacialentiscusleaves (AEPL) (50, 100 and 200 mg/kg) against kidney stones formation and gastric ulcer induced by ethylene glycol (EG) and by HCl/Ethanol respectively. In EG experiment, blood was collected to estimate calcium, phosphorus, creatinine and urea levels. The presence of stones was detected by microscopic observation of renal tissue sections. The obtained results showed that the higher amounts of calcium, phosphorus, urea and creatinine observed in EG/AC treated animals were decreased by AEPL treatment. Histology observation indicated that the number of calcifications in renal tissues of rats treated by AEPL given orally, were significantly reduced compared to the EG/AC group. On the other hand, the important antiulcerogenic effect observed in rat treated with AEPL is dose dependent. This data suggests that AEPL has a protective property against urolithiasisand gastric ulcer justifying its popular use in Morocco as an anti-urolithiasis and anti-ulcer agent.

Keywords: Plentiscus; Urolithiasis; Ethylene glycol; stone formation; gastric ulcer.