SERUM LEVELS OF IL-6 & IMMUNOGLOBULIN'S (IGA. IGM .IGE) EXPRESSION IN HUMAN INFECTED WITH AMOEBIASIS

Ali Naeem Salman* and Samaa Faez K.

ABSTRACT

In this work (70) serum samples of patients suffered from diarrhea and infected with Entamoeba histolytica and (30) non infected considered group control were examined to evaluate the IL-6 concentration by ELISA method also measured the concentration of IGA,IGM,IGE by Enzyme linked immune sorbent assay between two groups first group patients composed (60) child infected and second group composed (24) child non infected. Recent this study revealed that there was an increasing in concentration of the studied cytokine (IL-6) in patient serum (407.78) pg./ml in a comparison with control group with ahighly significant differences (p< 0.05). Moreover, the present results showed that mean concentration of IGE,IGA in patients with intestinal amoebiasis was more than those of control group with significant differences (p<0.05), while there was a significant differences in concentration of IGM between two groups, (Although there is an increasing in it`s concentration in some patients more than the normal values).The data revealed significant differences (p<0.05) in concentration two f IL-6 between two studied group. The immune system response to amoebiasis infection was detected through expression of interleukins such as il-6.

Keywords: Amoebiasis , Immunity, cytokines, IgA, IgM, IgE.