AN INVITRO STUDY ON EFFICACY OF CHLOROQUINE AGAINST PSEUDOMONAS, AND STAPHYLOCOCCI.

Dr. Saivisveswar.K.N, Dr. Jagadeesh K and Dr. Shreenivas P Revankar*

ABSTRACT

Chloroquine is a 4-aminoquinoline drug used in the treatment or prevention of malaria. Staphylococcus aureus is a Gram-positive coccal bacterium that is a member of the Firmicutes, and is frequently found in the human respiratory tract and on the skin. Pseudomonas aeruginosa is a common bacterium that can cause disease in animals, including humans. It is citrate, catalase and oxidase positive. It is found in soil, water, skin flora, and most man-made environments throughout the world. Antibiotic sensitivity is the susceptibility of bacteria to antibiotics. Antibiotic susceptibility testing (AST) is usually carried out to determine which antibiotic will be most successful in treating a bacterial infection in vivo. The objective of this study is to establish the efficacy of Chloroquine against common pathogenic bacteria such as pseudomonas and Staphylococci. Results: Chloroquine phosphate was found to show a broad range antibacterial activity. Staphylococcus aureus has almost same efficacy when compared to that of the standard amoxicillin-clavulanic acid combination. Pseudomonas is the most sensitive of all the organisms that were studied showing more susceptibility to Chloroquine than to the standard drug combination used here to compare.

Keywords: Chloroquine, Antimicrobial Susceptibility Test, Kirby-Bauer, Staphylococcus aureus, Pseudomonas.