EFFECT OF LIGNOCAINE & ADRENALINE COMBINATION AS LOCAL ANESTHETIC ON ECG PARAMETERS

Annasaheb Gagare, Sinare B. R.*, Prashant Patel, Rahul Kunkulol and Narwane Sandeep

ABSTRACT

Background: The effect of Ligocaine-Adrenaline combination as local anesthetic during dental procedures on healthy individuals has been scarcely studied. The objective of the study was to study effects of Lignocaine 2% & Adrenaline 1:80000 combination on various ECG parameters in dental patients without other co morbidities undergoing dental procedures. Methods: This was a prospective, observational clinical study done in collaboration with the Department of Oral & Maxillofacial Surgery, Rural Dental College & Hospital, Loni. Patients scheduled for oral surgeries under local anesthesia with Lignocaine and adrenaline combination of age 18 years or above of either gender willing to give written informed consent were included in the study. A standard 12- lead ECG (25 mm/s) was recorded for each patient before administration of drugs (Basal), during dental procedure (Intraoperative) and immediately after completion of surgical procedure. Results: Total 75 patients were included in the study. The increase in heart rate from basal (88.84 ± 7.77 beats per minute) to intra operative (89.52 ± 7.50) and postoperative (90.16 ± 7.41) was statistically significant. There was statistically significant decrease seen in the PR and RR interval when the basal, intra operative and post operative values were compared. There was statistically significant decrease in QT and QTc interval, QT and QTc dispersion. Conclusion: Effects of lignocaine-adrenaline combinations on electrocardiographic parameters are minimal and clinically irrelevant in healthy individuals.

Keywords: Lignocaine & Adrenaline combination, Local anesthetic, ECG parameters.