IMMUNOLOGICAL DIFFERENCES THREE NEGATIVE AND LUMINAL BREAST CANCER IN YOUNG PATIENTS

Alimhodzhaeva L.T.*, Zakirova L.T., Yusupova N.B., Khodjaev A.A., Nigmanova N.A., Norbekova M.Kh., Zakhirova N.N., Abdullaeva G.D., Narzieva D.F. and Shadmanova D.S.

ABSTRACT

Recent studies have completely changed the idea of the course of malignant diseases, in particular breast cancer (BC). For practical oncology, the addition to the conventional TNM clinical and morphological classification with the concept of four molecular biological subtypes of breast cancer has become important. Genetic classification included a variety of disease options: from luminal A, luminal B to three times negative. A completely new round of research on the biological activity of breast cancer has changed not only the clinical understanding of the process of active metastasis or its long-term latent existence in the body, but also the tactics of treatment based on the results of relapse-free and overall survival. Luminal A and three times negative variants of breast cancer are polar in many ways. Thus, the early luminal A type of breast cancer with a low risk of recurrence is subject to the hormonal system with a presumably intact immunological link of homeostasis at the system level. The standard of treatment for early luminal A breast cancer is reduced to surgery and consistent hormone therapy, since the use of chemotherapy reduces long-term results due to its toxicity, especially in the low-risk group. Three times negative breast cancer is autonomous from hormonal influence and, it is possible, it has high immunogenicity. Such patients continue the treatment for a long time in the form of sequential chemotherapy, up to regimens with compacted doses of cytostatics. The high risk of redivoting this type of breast cancer depends on the effects of growth factors and the microenvironment. With luminal A and a threefold negative type of breast cancer, the relationship between the body and the immune system is different. If in the luminal A subtype of breast cancer, there are fewer violations on the part of the immune system, then in the case of a threefold negative subtype, the violations are more pronounced.

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