MUCOADHESIVE BUCCAL FILM- REVIEW

K. Malleswari*, D. Rama Brahma Reddy and B. Kusumanjali

ABSTRACT

Buccal drug delivery leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Buccal route is an attractive route of administration for systemic drug delivery. Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases. This article aims to review the recent developments in the buccal adhesive drug delivery systems to provide basic principles to the young scientists, which will be useful to circumvent the difficulties associated with the formulation design. Drugs that are administered via the buccal mucosa directly enter the systemic circulation, thereby avoiding hepatic first pass metabolism therefore, this administration route is useful for improving the bioavailability of drugs that are subjected to an extensive first pass effect when delivered orally for oral mucosal route of administration, various types of dosage forms can be prepared. A sublingual tablet can afford rapid drug absorption and a prompt pharmacological effect, however, the duration of delivery is short owing the administered dose due to swallowing. To avoid such loses, a patch can be formulated that is located on the buccal mucosa of the oral cavity. The amount of drug reaching the systemic circulation is limited by the area of the mucosa that the patch covers, which for patient comfort reasons, is relatively small.

Keywords: Mucoadhesive, Buccal drug delivery, films.