MICROSPHERES-A REVIEW ARTICLE

K. Malleswari*, D. Rama Brahma Reddy, U. Sravani and K. Sonia Chowdary

ABSTRACT

Microspheres are characteristically free flowing powders consisting of proteins or synthetic/natural polymers having a particle size ranging from 1-1000μm micrometers. Oral modified-release multiple-unit dosage forms have always been more effective therapeutic alternative to conventional or immediate release single-unit dosage forms. With regards to the final dosage form, the multi particulates are usually formulated into microspheres and filling them into hard gelatin capsules. Microspheres received much attention not only for prolonged release, but also for targeting of drugs. Microspheres are various types like Bio adhesive microspheres, Magnetic microspheres, Floating microspheres, Radioactive microspheres, Polymeric microspheres, Biodegradable polymer- i.e microspheres, Synthetic polymeric microspheres. The current aim of this review is to study various aspects of the microparticles including types and evaluation tests.

Keywords: Microspheres, types of microspheres, evaluation of microspheres.