THE POSSIBILITIES OF MOLECULAR-BIOLOGICAL MARKERS IN SUPPRODUCTIVE IMMUNOTHERAPY IN PATIENTS WITH ONCINE-INTAL DISEASES

*Kamishov S. V. and Tillyashaykhov M. N.

ABSTRACT

The aim of the study was to study the expression of molecular biological tumor markers in patients with cervical cancer and ovarian cancer, and their effect on the course of accompanying immunotherapy. It was shown that the accompanying immunotherapy scheme, including EIPHT with plasmapheresis, had the greatest effect in increasing the 5-year survival of patients with cervical cancer and OC. The analysis of the correlation of the level of tumor markers and 5-year survival of patients suggests that a positive level of p53, VEGF and Ki-67 in patients with cervical cancer and OC may, along with the high proliferative activity of the tumor, be the basis for carrying out this category of accompanying patients immunotherapy with EIPHT, which can significantly increase the effectiveness of standard antitumor treatment regimens. With a positive level of these tumor markers, along with a high proliferative activity of the tumor, it is possible to recommend carrying out an accompanying immunotherapy with EIPHT with plasmapheresis.

Keywords: Cervical cancer, ovarian cancer, molecular biological markers, immunotherapy, accompanying therapy.