EFFECT OF ETHINYL ESTRADIOL CYPROTERONE COMBINED WITH METFORMIN ON CLINICAL OUTCOME AND COMPLICATIONS OF PATIENTS WITH POLYCYSTIC OVARY SYNDROME INFERTILITY

Balqisa Osman Heile and Xuefeng Wang*

ABSTRACT

Purpose: To investigate the effect of Ethinyl Estradiol Cyproterone combined with Metformin in the treatment of infertility with polycystic ovary syndrome and its impact on complications, and provide reference value for clinical treatment. 112 patients admitted to our hospital from January 2016 to January 1818 were randomly divided into study group and control group. In the control group, 56 cases were given ethinyl estradiol progesterone orally; 56 cases in the study group, and Metformin was added orally on the above basis. The changes of endocrine level, blood lipid level and general condition of the two groups were recorded before and after treatment. The ovulation pregnancy and complications were compared between the two groups. Result: Before treatment, there was no significant difference in endocrine level between the two groups (P>0.05). After treatment, the LH of the study group was (9.18±1.05) U/L, T was (49.32±5.31) μg/L, and INS was (8.45). ±0.89) U/L, FPG was (4.25±0.49) mmol/L, and HOMA-IR was (1.75±0.29), compared with the control group (P<0.05). After treatment, the TC of the study group was (3.48±0.65) mmol/L, TG was (1.17±0.31) mmol/L, and LDL-C was (2.05±0.39) mmol/L, which was significantly lower than the control group. The indexes were higher than the control group, and the difference was statistically significant (P<0.05). Before treatment, there was no significant difference in body general indicators between the two groups (P>0.05). After treatment, the BMI of the study group was (20.03±2.07) Kg/m2, WHR was (0.72±0.11), the hairy score was (1.05±0.19), and the acne score was (2.35±0.39), compared with the control group (P< 0.05). Among the study group, the periodic ovulation rate was 91.03%, the ovulation rate was 75.22%, and the pregnancy rate was 37.5%, which was significantly different from the control group of 75, 58.14% and 17.86% (P<0.05). Among the patients in the study group, 1 patient had elevated blood pressure, 1 patient had dizziness headache, and 1 patient had ovarian stimulation syndrome. The complication rate was 5.36%, which was significantly lower than that of the control group (28.57%). The difference was statistically significant (P<0.05). Conclusion: Combined drug use can effectively improve the endocrine hormone level, blood lipid level and body general index of the patients, which is conducive to the improvement of ovulation rate and pregnancy success rate, as well as the improvement of patients' quality of life and family relations. In addition, with less adverse reactions, the drug safety is high, which is worthy of clinical application.

Keywords: P - COS; Infertility; Ethinyl estradiol Cyproterone; Metformin.