ROLE OF MR DIFFUSION WEIGHTED IMAGING IN THE EVALUATION OF ADULT INTRACRANIAL NEOPLASMS
Dr. Nahas K M, *Dr. Ashok Kumar Y. G, Dr. Najah Mohamed Nizam, Dr. Abhinay A.
ABSTRACT
Aim: The aim of the study was to compare the efficacy of Diffusion weighted imaging in predicting the histology of intracranial neoplasms and to correlate with WHO grading. Methods and Materials: This prospective study was performed in 41 patients with intracranial tumours.Diffusion gradients and ADC maps were calculated within the tumor, the peritumoral region, and the contralateral normal appearing white matter .The ratios were calculated by dividing the maximum value in the tumor and in the peritumoral region by the value in the contralateral normal-appearing white matter. For statistical analysis Student independent t-test and ROC curve analysis was performed. Results: The difference in the mean ADCt ratios of high and low grade gliomas were statistically significant. To identify high-grade gliomas, a cut off of < 1.217 for ADCt yielded 70 % sensitivity and 20 % specificity. ADCt and ADCp ratios showed no significant difference to differentiate between high grade glioma and metastasis. Conclusion: Diffusion weighted images showed very good diagnostic accuracy in grading glial tumors, however had limitation in differentiate between high grade glioma and metastasis.
Keywords: Glioma, Magnetic resonance imaging, Diffusion, Tumour.
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