ASSESSMENT OF SOME BIOCHEMICAL PARAMETERS AMONG SMOKERS

Obodo Basil Nnaemeka*, Iyevhobu Kenneth O., Ighodaro Faith I., Omolumen L. E., Abinokhauno Solomon, Ugwu M. C.

ABSTRACT

This study was designed to evaluate the serum levels of creatinine, urea and activities of Alkaline phosphatase (ALP), Gamma glutamyl transferase (GGT), Creatine kinase (CK) and Lactate dehydydrogenase (LDH) among cigarette smokers in Ekpoma, Edo State. This study employed a total of 80 subjects consisting of 50 cigarette smokers and 30 non cigarette smokers which served as the control. All laboratory analysis was carried out using Randox kit assay system. Creatinine values among cigarette smokers (0.81 ± 0.11mg/dl) were significantly higher (P<0.05) when compared with the control (0.73 ± 0.10 mg/dl). Similarly, serum urea levels among cigarette smokers (20.60 ± 1.58mg/dl) were also found to be significantly higher (P<0.05) than the control (17.82 ± 0.49 mg/dl). Comparatively, activities of both ALP (23.80 ± 2.70U/L) and GGT (32.43 ± 2.46U/L) in cigarette smokers were significantly higher (P<0.05) when compared with their respective controls (19.54 ± 1.30 U/L and 23.50 ± 1.60U/L). It was also observed in this study that the levels of these parameters were significantly higher as age increases. Also, activities of CK was significantly higher (p<0.05) among cigarette smokers (173.03±47.31 U/L) when compared with the control (149.10±59.98 U/L). The activities of LDH were significantly higher among cigarette smokers (337.55 ± 119.11 U/L) when compared with the control (302.62 ± 93.80 U/L). Similarly there was a significant alteration when ALP, GGT, CK, LDH, creatinine, Urea were compared with exposure to cigarette smoking. Therefore, this study showed that the serum biochemical parameters investigated were significantly affected by smoking.

Keywords: Smokers, Cigarette, Biochemical, Creatinine, Urea.