MOLECULAR LEVEL DOCKING OF HEPATOCYTE NUCLEAR FACTOR (HNF)-1 ALPHA IS ASSOCIATED WITH MATURITY-ONSET DIABETES OF THE YOUNG (MODY) 3

*S. K. Ammaji, V. Manikanta, G. Pavan Kumar, N. Tirumala Rani and K. Bhagya Sree

ABSTRACT

Heterozygous germline mutation of hepatocyte nuclear factor (HNF)1 alpha are associated with mature onset of diabetes of the young (MODY) 3 in recently gene also reported liver adenoma it characterized by the presence of numerous adenoma within normal hepatic parenchyma. Transcription factor is important for cell differentiation in pancreatic beta cells that impair the cell mass and function which lead to rises of blood glucose level in young’s. By treating these condition to use sulphonyl urea derivatives along with insulin. The present work deals designing a suitable drug with molecular target to perform docking which is act on HNF1alpha receptor to control the differentiation of pancreatic beta cells regulate insulin secretion for controlling blood glucose level. By using different tools, data bases minimizing the targeted molecule and design a compound library. Out of the various compounds designed the best molecule which was obtained was found to be 2-amino nanoic acid.

Keywords: MODY, molecular docking, HNF-1A, ADMET study.