DYNAMICS OF CLINICAL AND IMMUNOLOGICAL INDICATORS OF WOMEN WITH CERVICAL INTRAEPTELIAL NEVA PLASIA UNDER THE INFLUENCE OF IMMUNOCORRIGATING THERAPY

A. N. Kalandarova, T. U. Aripova and *D. A. Musakhodjaeva

ABSTRACT

Background: In the structure of gynecological diseases cervical pathology is 15-40%. Almost all of these infections occur against the background of a secondary immunodeficiency state and provoke its further development, aggravating the course of the disease. Objective: The results of complex examination and treatment of cervical intraepithelial neoplasia (CIN) in 64 women were studied. Methods: The level of cellular immunity parameters (CD3+, CD4+, CD8+, CD16+, CD25+ and CD95+) in the dynamics of treatment was studied. Result: It was identified that the evidenc- of immunological defect correlated with the nature of pathological changes in the cervical intraepithelial tissue, indicating the involvement of the immune system in the pathogenesis of CIN. Immunocorrection was showed out using the medicine "Bioflazid" in combination therapy. Conclusion: The recieved data confirm the effectiveness of "Bioflazid" in complex treatment, in which there is a positive dynamics of not only clinical indicators, but also the parameters of the immune system.

Keywords: Cervical intraepithelial neoplasia, immunity, immunocorrection.