INTERLEUKIN-1 GENE POLYMORPHISMS ROLE IN DEVELOPMENT OF CHRONIC GLOMERULONEPHRITIS AND ESRD

M. Ruzibakieva*, T. Aripova, Z. Azizova, U. Yuldasev, P. Sultanov, D. Sadikov

ABSTRACT

Chronic glomerulonephritis (CG), chronic renal failure (CRF) are the majority of instances to end stage renal disease (ESRD) which is the cause of renal replacement therapy. It was noted that patients with chronic kidney disease have a greater inflammatory response compared with healthy people. As is generally known, inflammation is partly regulated by the genes of the interleukin-1 (IL-1) gene cluster. We supposed that some single nucleotide polymorphisms (SNPs) in this gene cluster may be associated with the risk of development of CG and ESRD. We have studied polymorphisms in the IL-1 gene cluster in a group of patients with CG and ESRD (n=74) and 66 controls. These individuals were genotyped for 3 single nucleotide polymorphisms in the IL-1beta genes - IL-1beta- 31T/C, -511T/C, 3953C/T SNPs. It was found out, that IL-1beta- 31T and -511 T, TT are associated with CG and ESRD in Uzbeks. At the analysis of haplotype combinations two haplotypes of the IL-1 gene 31T/C, -511T/C, 3953C/T SNPs are associated with ESRD -31T/-511C/3953T and -31C/-511T/3953T. These findings are playing an important role in the study of associations between IL1 SNPs genotype and CG and ESRD in Uzbeks, and shows that polymorphisms in the IL-1 gene cluster affect the risk of development of ESRD.

Keywords: Chronic Renal Failure CRF, CKD, ESRD, Glomerulonephritis, IL1.