GEL BASED SOLID LIPID NANOPARTICLE OF AN ANTIBIOTIC DRUG FOR OCULAR USE

Nida Parveen*

ABSTRACT

The aim of the present study was focused on the development of solid lipid nanoparticles based gelling system of an antibiotic drug to be administered through ocular route. Four formulations (P1, P2, P3 & P4) of solid lipid nanoparticles were prepared containing prednisolone. Solid lipid nanoparticles were prepared by emulsification followed by sonication method. Prepared prednisolone containing solid lipid nanoparticles were evaluated for particle size, shape, surface morphology, drug content and in-vitro drug release studies. The average particle size was found to be in range 349.2 nm, the particles were uniform, spherical in shape and had 60 to 84.45%w/w of drug entrapped in it. The drug release from solid lipid nanoparticles showed sustained release of drug. All the formulation showed better result in terms of stability. Among the four formulations the best result were found with P1 formulation of Prednisolone. The solid lipid nanoparticles of prednisolone were incorporated in gel so as to make it suitable to be administered by ocular route. Solid lipid nanoparticles containing gel showed drug delivery up to 88.7%. Prednisolone nanoparticles loaded gel showed better result when compared with the prednisolone nanoparticles; because the release rate revealed that the gel gave higher release of drug initially for quick onset of action.

Keywords: Solid lipid nanoparticle (SLN), Prednisolone, Ocular route.