DESIGN AND EVALUATION OF LISINOPRIL FLOATING TABLET

Lubna T. E.* and Ibrahim Afsal V. T.

ABSTRACT

Lisinopril is an antihypertensive drug with 12 hr half life narrow absorption window and PH dependant solubility so the present study aimed to prolong it’s gastric residence time that entailed development of an optimised gastro retentive floating tablets(GRFTs).Tablets were fabricated by direct compression using hydroxy propyl methyl cellulose and carbopol 934 as release retained in polymers. The total floating time, swelling ability, buoyancy lag time and in vitro release studies were also carried out in 0.1N HCl(pH 1.2) at 37+/-0.5. Statistical data analysis revealed that the optimised formulation containing 21.91% HPMC and 50% carbachol934 had acceptable hardness. Optimum floating behaviour and 24 hr controlled releasepattern. The design succeeded to develop CVD-GRFTs with floating ability and controlled releasebehaviour that could increase solubility and improved it’s availability at the absorption site.

Keywords: gravity = (Df - Ds) gv Where, F= total vertical force, Df = fluid density, Ds = object density, v = volume and g = acceleration due to gravity. AIM The aim of the present study was to develop floating tablets of lisinopril to achieve prolong residence tim