FORMULATION AND EVALUATION OF MATRIX TABLET OF DILTIAZEM HYDROCHLORIDE FOR CONTROLLED RELEASE

Rashmitha N. M.*, C. N. Somashekhar, Shravya Lakshmi S. and T. Tamizh Mani

ABSTRACT

The present study is the development of controlled release matrix tablets of anti-hypertensive drug Diltiazem hydrochloride by direct compression method. Hydroxy propyl methyl cellulose (HPMC) LV15 and LV5 are used as rate retarding polymer. The effect of the different concentration of the polymer and the influence of different grade of HPMC on the release rate of drug was investigated. Diltiazem hydrochloride release from HPMC LV15 and HPMC LV5 matrices are mainly controlled by the drug – polymer ratio. The prepared matrix tablets were evaluated for post-compression parameters such as hardness, friability, thickness, % weight variation, % drug content and in-vitro dissolution test. From the in-vitro study F3 formulation showed better controlled release till 12 hrs, this is due to high viscosity grade with high ration of HPMC.

Keywords: Diltiazem hydrochloride, controlled release, Hydroxy propyl methyl cellulose, Dissolution.