EFFECT OF NIGELLA SATIVA OIL ON LIPID PROFILE IN PATIENTS OF CHRONIC KIDNEY DISEASE

Zafar Masood Ansari*, Shamama Nishat, Mohammad Nasiruddin

ABSTRACT

Aims: To study the efficacy and safety of add-on therapy of Nigella sativa oil on lipid profile in patients of Chronic Kidney Disease. Material and Methods: This prospective, comparative and open label study was performed in patients diagnosed with Chronic Kidney Disease (CKD) of stage 3 and 4. Patients were divided into two groups by randomization method. Patients in Group 1 (Control) received conservative management while in Group 2 (Test) received Nigella sativa oil (2.5 mL, orally, once daily) along with conservative management of CKD for 12 weeks. Lipid profile and kidney function test was done at 0, 6 and 12 weeks of treatment. Statistical analysis used: In each group, pre and post treatment values were calculated and compared with the help of Student’s Paired T-test and between the groups, Unpaired T-test was applied. Results: A more obvious progressive improvement in lipid profile and renal function as well as clinical features was detected in test group as compared to control group after 12 weeks. There was improvement in lipid profile and decline in blood urea, serum creatinine and 24-hour total urinary protein (TUP) level, while there was rise in 24-hour total urinary volume (TUV) and glomerular filtration rate (GFR). Conclusions: supplementation of Nigella sativa oil with conservative management of CKD is effective and safe in improving lipid profile in addition to preventing the advancement of disease in patients of CKD of stage 3 and 4.

Keywords: Nigella sativa oil, Chronic Kidney Disease, Lipid Profile, Serum Creatinine.