PREPARATION, OPTIMIZATION AND EVALUATION OF CELECOXIB PRONIOSOMAL GEL

Sangeeta Bohra, Srikanth* and Anand Kumar Y.

ABSTRACT

In the present work an attempt was made to formulate and evaluate celecoxib proniosomal gels. The proniosomal gels were prepared by coacervation phase separation method using nonionic surfactants (span 60, span 40): cholesterol, lecithin and drug then it was incorporated into 0.75% of carbopol gel. Further formulations were evaluated for entrapment efficiency, drug content, size and shape, in vitro drug release and skin irritation studies. The particle size distribution of all formulations were in the range 4.43-4.91μ. Zeta potential value and zeta potential analysis were-78.3Mv and 1442 d.nm for (SF3) formulation. The skin irritation potential was 0.31 suggesting the (SF3) formulation was nonirritant to the rabbit skin. The highest entrapment efficiency was found in formulation (SF3) 96.01 ± 0.45% and cumulative percent drug release was observed with 86.19±0.15 over the period of 24h. In vitro kinetic model fitting suggest that the best fit model was hixon crowel with korsemayer peppas exponential „n‟ value <0.5 indicating that drug was released by non fickian mechanism. These results indicate that proniosomal gels have a promising carrier for the transdermal delivery of celecoxib. Thus celecoxib can be formulated into a low dose proniosomal gel that can save the recipient from the adverse effects of large doses.

Keywords: Proniosomal gel, Celecoxib, Cholesterol, Span 60, Span 40, Lecithin.