ASSESSMENT OF THE FORMATION OF IMMUNOLOGICAL DISTURBANCES IN MEN WITH AZOOSPERMIYA

*Fayzullaeva N. Ya., Musakhodjaeva D. A., Ruzibakieva M. R., Yarmukhamedov A. S., Nurmukhamedov B. B., Azizova Z. Sh. and Djumaeva D. N.

ABSTRACT

A study was conducted to study the state of the immune system in 132 men with primary infertility. It was revealed that this contingent had an imbalance in the content of some parameters of the immune system. Thus, the level of CD3 + - and CD4 + lymphocytes was reduced, the killer activity was increased. The content of CD20 + lymphocytes and the concentration of IgG and IgA were elevated. The level of pro-inflammatory cytokines (IL-2, IL-6, TNFα) in the examined patients was elevated. The results indicate the important pathogenetic role of the immune mechanisms in men with primary infertility.

Keywords: Male infertility, immunity, cytokines.