COLISTIN USAGE—A CHALLENGE TO THE PHYSICIAN

Dr. Rajashree Panigrahy, Dr. Priyadarshini Bhoi* and Dr. Suren Kumar Das

ABSTRACT

Colistin, a 50 year-old antibiotic, is increasingly being used in the 21st century for the treatment of life-threatening infections. But the rampant use of the drug creates a man-made resistant in the bacteria towards the drug. Because few, if any, new antibiotics with activity against MDR Gram-negative bacteria will be available within the next several years, it is essential that colistin is used in ways that maximize its antibacterial efficacy and minimize toxicity and development of resistance. Recent developments have improved use of colistin in the 21st century, every effort must be made to optimise the clinical use of the colistin to maximise their efficacy while minimising the emergence of resistance and toxicity.

Keywords: Colistin, Multi-drug resistant organism.