NANOSTRUCTURED LIPID CARRIERS, METHODS OF PREPARATION AND APPLICATIONS: REVIEW

Kiran Kumari*, Anupam Kr. Sachan and Saurabh Singh

ABSTRACT

Nanostructured lipid transporters (NLCs) are changed solid lipid nanoparticles (SLNs) that hold the qualities of the SLN, enhance drug stability and loading limit, and avoid drug spillage. Polymer nanoparticles (PNPs) are a vital part of drug delivery. These nanoparticles can viably guide drug delivery to explicit targets and enhance drug stability and controlled drug release. Lipid– polymer nanoparticles (PLNs), another kind of bearer that consolidates liposomes and polymers, have been utilized in recent years. These nanoparticles have the integral focal points of PNPs and liposomes. A PLN is made out of a core– shell structure; the polymer center gives a steady structure and the phospholipid shell offers great biocompatibility. All things considered, the two parts increment the drug epitome productivity rate, encourage surface alteration and anticipate spillage of water-dissolvable drugs. Thus, we have explored the present condition of advancement for the NLCs', PNPs’ and PLNs' structures, preparations, and applications in the course of recent years, to give the premise to additionally examine on a controlled release drug delivery system.

Keywords: Nanostructured lipid carriers, Polymeric nanoparticles, Lipid-polymer hybrid nanoparticles.