LIQUISOLID TECHNIQUE: A NOVEL CONCEPT OF DRUG DELIVERY SYSTEM TO ENHANCE DISSOLUTION

Vinay A. P.*, Mamatha G. T., Parthiban S. and Senthil Kumar G. P.

ABSTRACT

Dissolution of drug and its release from the dosage form have basic impact on bioavailability. Bioavailability of drugs depends on its solubility. Solubility is major challenge for the pharmaceutical industry with the developments of new pharmaceuticals. About 40% of the newly discovered drugs fall into poor water soluble or water insoluble categories. The aqueous solubility of poorly water-soluble drugs is usually less than 100ug/ml. There are so many techniques to enhance the dissolution of poorly soluble drugs, in which the liquisolid compacts is a promising technique. The Liquisolid compact system is a novel concept of drug delivery system (NDDS) that can improve the dissolution rate of water insoluble drugs. This liquisolid technique is based upon dissolving the insoluble drug in the non-volatile solvent and admixture of drug loaded solutions with appropriate carrier and coating materials to convert into acceptably flowing and compressible powders. These free flowing powders are subjected to compression for tablet or filled in capsules.

Keywords: Liquisolid Compacts, Non-Volatile Solvent, Carrier, Coating Material.