TWO HOURS POSTPRANDIAL EFFECT OF COMMONLY USED SOFT DRINK (COKE) ON PLASMA GLUCOSE LEVEL IN NIGERIA

Agbesor Innocent Nwouzuke*, Zaccheaus Awortu Jeremiah and Bashir Hamza

ABSTRACT

Two hours postprandial effect of oral administration of soft drink (coke) was carried out on 111 apparently healthy students between the age 17-35 years in Rivers State University, Nkpolu, Port Harcourt. A total of 50 samples were collected from Females aged 21-30 years and 61 samples from Males aged 17-35 years. The results of the analysis in group A (one bottle of coke) showed mean fasting plasma glucose concentration of 4.0+0.255Mmol/l among females and 4.1+0.453Mmol/l among males. After oral administration of one bottle of coke, mean plasma concentration for both sexes increased to 4.1+0.315Mmol/l for females and 4.5+0.292 Mmol/l for males. Statistical evaluation of results showed significant difference in mean plasma fasting value and after oral administration of one bottle of coke (p< 0.05). In group B (two bottles of coke) subjects, mean fasting plasma glucose in females was 4.0+0.242Mmol/l and in males 4.2+0.382Mmol/l. After oral administration of two bottles of coke, the mean plasma glucose value for females increased to 4.6+0.251Mmol/l and males to 4.7+0.362Mmol/l. Statistical evaluation of results showed significant difference between mean plasma fasting value and value after oral administration of two bottles of coke (p<0.05). The oral glucose tolerance test (OGTT) graph for both taken one and two bottles of 350ml of coke did not return to the fasting level. Hence oral administration of one or two bottles of coke can enhance the development of postprandial hyperglycaemia in those subjects that are genetically predisposed to diabetes mellitus.

Keywords: Coke, 2-hours postprandial, OGTT, Hyperglycaemia, Diabetes Mellitus.