DESIGN AND EVALUATION OF ISOSORBIDE DINITRATE ORODISPERSIBLE FILM

Haritha K.H.*, Sivakumar R., Reshma Fathima K. and Haribabu Y.

ABSTRACT

The concept of the development of Orodispersible film (ODF) formulation mainly to improve the drug efficacy, bioavailability and patient compliance. The objective of the present study was to develop orodispersible film containing Isosorbide dinitrate (ISDN) for the treatment of angina pectoris. Five formulations are prepared for the trial using solvent casting method .The film was evaluated for FTIR, Melting point, appearance, weight variation thickness, folding endurance, tensile strength, in-vitro diffusion study, moisture %, in-vitro dispersion study. Based on the evaluation studies best formulation F3 is selected as the best batch. The best batch subjected for the ex-vivo permeation study by using goat tongue membrane. Based on the study the FT-IR study revealed that there was no drug-polymer interaction. The folding endurance test ensured that the films had sufficient brittleness. The films were dispersed in the time range of 120-160 sec and drug release was found to be 98.4% at the time of 10min.

Keywords: Orodispersible film, thin strip, Solvent casting method, goat tongue.