REVIEW ON NATURAL PLANT PRODUCTS USED IN TREATMENT OF GOUT

Ankit Sharma*, Siddhraj S. Sisodia and Vandana Narvariya

ABSTRACT

Gout is a common metabolic disorder affecting humans with prevalence rate of 1-2% in developed countries. Normal range of uric acid in human is male (2.5 to 6 mg/dl) and female (1.5 to 6 mg/dl). It is characterized by marked hyperuricemia (increase level of serum uric acid) above 6.8 mg/dl. Uric acid crystallizes in the form of monosodium urate and deposits in joints, tendon and in the surrounding tissues that manifested as a sudden burning pain, swelling, redness and tenderness in joints. Gout is the common cause of arthritis in elder person (age above 50 yrs.). Ratio of occurrence of gout in men to female is 3.6:1. There are several drugs such as allopurinol, probenecid etc. are used in management of gout, but these are being chemically in nature, they are prone to cause side-effects such as rashes, hypersensitivity, convulsions, respiratory failures, Stevens - Johnson syndrome (rare) etc. Therefore, to avoid such side effects we need some herbal alternatives which are capable of inhibition of Xanthine Oxidase, which is responsible for the formation of uric acid. The aim of present review is to focus on some natural plant and their products which have potency to inhibit xanthine Oxidase enzyme and can be beneficial for management of gout. Toxicity of herbal drug is always less than chemical synthesized drugs.

Keywords: Uric acid, Hyperuricemia, Xanthine Oxidase, Gout, Ayurvedic drugs.