AN EVALUATION ON PHARMACOLOGICAL ACTIVITY OF HEVEA BRASILIENSIS

Saifuddin Mohammad Seeam*, Md. Emdadul Haque, Faisal Ahmed Chowdhury, Anik Bhattacharjee,
Sayed Koushik Ahamed, Nigar Sultana Pinky

ABSTRACT

The biological investigation is carried out on Hevea brasiliensis, a plant belonging to the family Euphorbiaceae. The roots of Hevea brasiliensis was collected from the planted forest of Chittagong region of Bangladesh. It was extracted with methanol. The extract was used for the observation of analgesic and antidiarrheal activity. Extract of Hevea brasiliensis has showed significant (P value<0.001) analgesic activity in mice producing an inhibition of 21.62% and 36.53% from extract(250 mg/kg) and extract (500 mg/kg) respectively, where Diclofenac sodium (Positive control) had an inhibition of 45.02%.In antidiarrheal test, percentage of distance travelled by charcoal for control, loperamide, extract (250mg/kg) and extract(500mg/kg) were 89.32%, 40.19%, 62.61% and 56.98% respectively, that indicate reduction in gastrointestinal motility.

Keywords: Analgesic, Antidiarrhea, gastrointestinal motility, Positive control, biological investigation.