REVIEW ON BI-LAYER TABLET: AN EMERGING TREND

Sudarshan B. Kakad* and Dr. Punit R. Rachh

ABSTRACT

Controlled release dosage form is a term used to describe the dosage forms having drug release features based on the time, course and/or location and which are designed to accomplish therapeutic or convenience objectives which are not offered by conventional release dosage forms. Whereas immediate release drug delivery system is intended to disintegrate rapidly and exhibits instant drug release. However, it is also associated with fluctuations in drug plasma levels, which leads to reduction or loss in drug effectiveness or increased incidence of side-effects. Therefore, to compensate the dip in drug plasma concentration due to metabolism and excretion, it is necessary to administrate the dosage form several times per day. Bilayer tablet is the novel technology for the development of immediate release and controlled release formulation. Developing a combination of two or more active pharmaceutical ingredients in a single dosage form is known as a bilayer tablet. It is more suitable for gradual release of two active ingredients in combination. This technology is an excellent improved technique for providing combine release pattern of drug i.e. immediate release and sustained release or two different categories. The present review focuses on formulation and evaluation aspects of bilayer tablets.

Keywords: Bilayer tablet, controlled release, immediate release etc.