EFFECTS OF CURCUMA LONGA L., CURCUMA AROMATICA SALISB., ZINGIBER OFFICINALE ROSC. EXTRACT ON INFLAMMATORY TEMPOROMANDIBULAR JOINT PAIN IN RAT'S

Tae-Heon Kim, Hee Jin Kim and Min Kyung Lee*

ABSTRACT

Objective: Zingiberaceae plants(Curcuma longa L. (C.L), Curcuma aromatica Salisb. (C.A) and Zingiber officinale Rosc. (Z.O)) which are well known as effects of anti-inflammation or anti-nociception. We investigated that the Zingiberaceae plants are involved in control of inflammatory temporomandibular joint(TMJ) pain in rats. Methods: Male Sprague-Dawley rats weighing 240-280 g were used in this study. Experiments were carried out using inflammatiry pain model that was caused by the injection of 5% formalin into the TMJ(30 ㎕). The number of scratching or rubbing to the injection site was recorded for 9 consecutive 5-minute intervals following injection of formalin. The experimental groups were separated into temporomandibular joint pain; control group (formalin, 5%), vehicle group (5% formalin after sodium carboxymethyl cellulose), single administration group, single mixed administration group, repeated administration group. The experiments were carried out various concentrations of Zingiberaceae plants extract. Results: Consequently, oral administration of C.L, C.A, and Z.O (p.o., concentrations of 12.5, 25 mg/ml) in inflammatory pain model significantly decrease the nociceptive behavior in a concentration dependent manner. And it tended to decrease at low concentration (6.25 mg/ml) of single mixed and repeated administration more than single administration. Conclusions: These results suggest that C.L, C.A, and Z.O extract administration regulate the inflammatory TMJ pain. Therefore, C.L, C.A, and Z.O extract may be a potential therapeutic treatment for inflammatory TMJ pain.

Keywords: Curcuma longa L., Curcuma aromatica Salisb., Zingiber officinale Rosc.., TMJ, Inflammation.