A REVIEW ON - DEVELOPMENT OF ORAL DISINTEGRATING TABLETS

Prasad M. S.*, Somashekhar C. N. and Senthil Kumar G. P.

ABSTRACT

Orally disintegrating tablets (ODTs) is one of the popular and widely accepted dosage forms, especially for the pediatric and geriatric patients. These dosage forms are placed in the mouth, allowed to dissolve in the saliva. They release the drug as soon as they come in contact with the saliva, thus avoiding the need for water during administration. They avoid the problem of dysphagia and improve patient compliance. Over the past three decades, orally disintegrating tablets (ODTs) have gained much attention as a preferred alternative to conventional oral dosage forms such as tablets and capsules. ODTs have gained considerable attention as preferred options to conventional tablet and capsule formulations. Various conventional and patented techniques have been employed for the development of ODTs. The techniques render the disintegration of tablet rapidly and dissolve in mouth without chewing or additional water intake. In the present review is focused on the ideal characteristics, formulation by different technologies and evaluation of ODTs are discussed.

Keywords: Oral disintegrating tablet, Advantages and disadvantages, Formulation challenges, Ideal Properties, Approaches for preparation of ODTs, Evaluation.