INDUCTION OF GAMMA-INTERFERON: THE POSSIBILITY OF USING RIBOSOMAL AND MEMBRANE FRACTIONS OF BACTERIA AS A MITOGEN

Ismailova A. A., Adylov D. G., Kasimova M. S., Petrova T. A., Rozumbetov R. J., Saydaliev A. E., Akbarov U. S., Rakhimjonov A. A.*

ABSTRACT

The study of induced cytokine production is one of the important and developing aspects of establishing the immunological state of the organism in the modern world. But due to the inaccessibility of classical mitogens remains poorly understood. The aim of the study was to identify the possibility of using the complex of ribosomal and membrane fractions of the bacteria Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes and Haemophilus influenzae to induce the production of gamma-interferon. The results showed the possibility and feasibility of their use as a mitogen in patients with chronic viral hepatitis B and C.

Keywords: Gamma-interferon, induction, ribosomal and membrane fractions.