FORMULATION AND IN VITRO EVALUATION OF SOLID DISPERSION SUSTAINED RELEASE TABLETS OF BENDROFLUMETHIAZIDE USING NATURAL AND SYNTHETIC POLYMER

Suresh Kumar P.*, Shameena S. K., Jagannath Patro V., Vanitha S. Bindhu T. and Sunitha C. H.

ABSTRACT

The aim of the present study was to develop sustained release formulation of Bendroflumethiazide to maintain constant therapeutic levels of the drug for over 12 hrs. Guar gum and HPMC grades were employed as polymers. The formulations prepared by direct compression method containing different concentration of polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation F8 showed better and desired drug release pattern i.e., 99.15% in 12 hours. It contains the HPMC K100M as sustained release material. It followed First order release kinetics mechanism.

Keywords: Bendroflumethiazide, Solid dispersion, Sustained release system, HPMC, Guar Gum.