FORMULATION DEVELOPMENT AND EVALUATION OF IVABRADINE HCL SUSTAINED RELEASE GASTRORETENTIVE FLOATING TABLETS

E. Uma Lakshmi*, K. Ashok and D. Dhachinamoorhi

ABSTRACT

The present study is an attempt to develop Gastro retentive floating tablets of Ivabradine HCL, with different polymers which releases a therapeutic amount of Ivabradine HCL to the proper site in the body and also to achieve and maintain the desired Ivabradine HCL concentration. The results of the drug-excipients compatibility by FTIR studies revealed that there was no chemical interaction between the pure drug and excipients. The Precompression parameters like bulk density, tapped density, Carr’s index and angle of repose were determined. The final formulation showed acceptable flow properties. The post compression parameters like the thickness, hardness, friability, weight variation, content uniformity, FLT and TFT and In vitro release, were carried out and the values were found to be within IP limits. Optimized formula containing Guar gum (F12) showed better release compare to other formulations and it followed first order kinetics with super caseII transport mechanism.

Keywords: of Ivabradine HCL, Direct compression, guar gum, Gastro retentive floating tablets.