STUDY OF PROTHROMBIN TIME (PT) AND CYTOGENETIC CHANGES IN PATIENTS WITH HBV IN WASIT PROVINCE

*Dr. Kadhum J. Gattia, Dr. Suhad F. Hasson and Nada H. Al-Badri

ABSTRACT

Viral hepatitis type B is a disease caused by entry of hepatitis B virus (HBV) to the body, reaching the liver, multiplication, and stimulates the patient's immune system to attack the infected cells therefore caused inflammation of hepatocytes. The study included 40 blood samples from patients with HBV compared with 25 blood samples from control. Patients were divided according to their age into two groups. Levels of prothrombin time (PT) was measured and cytogenetic tests: mitotic index (MI), micronucleus assay (MN) and nuclear division index (NDI) were measured for patients lymphocyte. The study showed a significant increase (P<0.05) in prothrombin time of the patients when compared with control to all age groups, as well as the results of mitotic index, micronucleus assay and nuclear division index were significantly increasing (P<0.05) indicates a defect in cells division.

Keywords: Hepatitis B Virus, Prothrombin Time, Mitotic Index, Micronucleus Assay, Nuclear Division Index.