ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CEFADROXIL: REVIEW

Kiran Kumar S.V.*, Jose Gnana Babu C. and Sowmya H.G.

ABSTRACT

Analytical method development and validation are the uninterrupted and free task associated with the research and development, quality control and quality assurance departments. Analytical procedures play a important role in the equivalence and risk assessment, management. Validations demonstrate that the analytical procedure is suitable for its intended applications. Literature survey reveals that the analytical methods based on UV spectrophotometry, RP-HPLC & HPTLC for the determination of Cefadroxil individually and in combination with other drugs. The methods were validated according to ICH guideline in terms of accuracy, precision, robustness, and other parameters. The reported methods are simple, sensitive and reproducible hence this can be used for the routine analysis of Cefadroxil in bulk and pharmaceutical dosage form.

Keywords: Cefadroxil, Literature Survey, Method Development, Validation, ICH Guidelines.