COMPARATIVE STUDIES OF VARIOUS ADSORBENT CARRIERS FOR ENHANCING DISSOLUTION PROFILE OF KETOPROFEN

Shinde Sunita S. and Kamble Sharad K.

ABSTRACT

In recent times, a large number of studies concerning the improvement of the dissolution rate of poorly water-soluble drugs is focused on the application of various porous materials as the drug carriers. These materials have attracted the attention of researchers owing to their outstanding properties such as large surface area, high pore volumes, microporosity and possibility of surface functionalization. In the present study, the biopharmaceutical performance of porous adsorbents as a carrier for the poorly water soluble drug Ketoprofen was investigated. Ketoprofen loaded different adsorbents with high specific surface area were used like Neusilin, Sylysia, Fujicalin and Aerosil, and it was done by solvent evaporation method. It was noticed that porous structure is responsible for an amorphous state of the drug and thus the improvement of its dissolution rate. From this research work it can be concluded that although the porous carrier particles help to enhance dissolution rate, including stability studies.

Keywords: Ketoprofen; Solvent evaporation method, Adsorbent carrier like Neusilin, Sylysia, Fujicalin and Aerosil, dissolution rate, stability study.